Interní Med. 2002; 4(8): 370-373

Deprese, kardiovaskulární choroby a nežádoucí kardiovaskulární účinky antidepresiv - II. část

MUDr. Jaroslav Slavíček CSc1, MUDr. Jiří Charvát CSc2, MUDr. Ivo Paclt CSc3, PhDr. Jakub Florian3
1 Fyziologický ústav I. Lékařské fakulty Univerzity Karlovy, Praha
2 Pracoviště specializovaných laboratoří IKEM, Praha
3 Psychiatrická klinika 1. LF UK a VFN Praha

Keywords: depression and cardiovascular disease, ischemic heart disease, stroke, cardiac arrhythmia, hypertension disease, aetiopathogenetic relationships, cardiotoxicity, lithium, tricyclic antidepressants, serotonin reuptake inhibitors, tricyclic antidepressants levels, QTc interval, QTc dispersion, ECG mapping.

Published: December 31, 2002  Show citation

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Slavíček J, Charvát J, Paclt I, Florian J. Deprese, kardiovaskulární choroby a nežádoucí kardiovaskulární účinky antidepresiv - II. část. Interní Med. 2002;4(8):370-373.

Sdělení podává přehled vztahů mezi depresivními poruchami a kardiovaskulárním onemocněním (ischemická porucha srdeční, infarkt myokardu a náhlá cévní mozková příhoda, částečně i hypertenzní choroba). Článek dále diskutuje kardiovaskulární účinky jednotlivých antidepresiv a lithia. Podrobně se zabývá vhodnou léčbou deprese u pacientů s kardiovaskulárním onemocněním. V závěru diskutuje možnost predikce kardiovaskulárních rizik antidepresivní léčby tricyklickými antidepresivy (parametr QTc, plazmatické hladiny tricyklických antidepresiv, QTc disperze, EKG mapování). Článek je rozdělen do dvou částí, v minulé části jsme se zabývali vztahem deprese a kardiovaskulárního systému. V této části diskutujeme problematiku antidepresiv a kardiovaskulárního systému.

Depression, cardiovascular disease and undesirable cardiovascular

side - effects of antidepressants - part 2nd</bold></p> The article gives a brief outline of the relationships between depressive disorders and cardiovascular disease (ischemic hearth disease, myocardial infarction, stroke and partly, hypertension disease). The cardiovascular effects of some antidepressants and lithium are discussed. The article specifically deals with the suitable treatment of depressive patients suffering from cardiovascular disease. The possibility for the prediction of the cardiovascular risk of antidepressive treatment by tricyclic antidepressants (meassurement of QTc, plasmatic level of tricyclic antidepressants, QTc dispersion, ECG mapping) is then discussed.

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