Interní Med. 2004; 6(4): 214-217

Kostní fluoróza

MUDr. Dagmar Opichalová1, MUDr. Pavel Horák CSc1, MUDr. Věra Vavrdová1, doc. MUDr. Martin Tichý CSc2
1 III. interní klinika FN a LF UP Olomouc
2 Ústav patologie FN a LF UP Olomouc

Published: December 31, 2004  Show citation

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Opichalová D, Horák P, Vavrdová V, Tichý M. Kostní fluoróza. Interní Med. 2004;6(4):214-217.

Fluoróza je onemocnění způsobené příjmem vysokých dávek fluoridových solí. Autoři se věnují demonstraci a rozboru případu fluorózy u pacientky užívající řadu let vysoké dávky fluoridů. Je podán přehled změn na skeletu s rozvojem osteosklerózy axiálního skeletu s odvápněním kortikální kosti v oblasti předloktí a s rozvojem osteomalacie. Jsou popsány změny v laboratorním spektru s charakteristickým vystupňováním novotvorby a resorpce kosti. Na závěr je uveden klinický popis onemocnění, jsou zdůrazněna rizika léčby fluoridy a podán přehled v praxi užívaných preparátů a jejich použitelnost.

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    References

    1. Bayer M, Blahoš J, Broulík P. Doporučené postupy pro diagnostiku a terapii postmenopauzální osteoporózy. Osteol bul 2003; 1: 8-12.
    2. Bayley TA, Harrison JE, Murray TM. Fluoride-induced fractures: relation to osteogenic effect. J Bone Min Res 5 1990; (Suppl 1): 217-222. Go to original source... Go to PubMed...
    3. Baylink DJ, Bernstein DS. The effect of fluoride therapy on metabolic bone disease. A histologic study. Clin Orthop 1967; 55: 51-85. Go to original source...
    4. Briancon D, Meunier PJ. Treatment of osteoporosis with fluoride, calcium and vitamin D. Ortop Clin North Am 1981; 12: 629-648. Go to original source...
    5. Broulík P. Osteoporóza. Praha: Maxdorf 1999: 92 s.
    6. Compston JE, Chadha S, Merrett AL. Osteomalacia developing during treatment of osteoporosis with sodium fluoride and vitamin D. Br Med J 1980; 281: 910-911. Go to original source... Go to PubMed...
    7. Farley JR, Wergedal JE, Baylink DJ. Fluoride directly stimulates proliferation and alkaline phosphatase activity of bone-forming cells. Science 1983; 222: 330-332. Go to original source... Go to PubMed...
    8. Gutteridge DH, Price RI, Kent GN. Spontaneous hip fractures in fluoride-treated patients: potencial causative factors. J Bone Min Res 5 1990; (Suppl 1): 205-215. Go to original source... Go to PubMed...
    9. Jowsey J, Riggs BL, Kelly PJ. Effect of combined therapy with sodium fluoride, vitamin D a calcium in osteoporosis. Am J Med 1972; 53: 43-49. Go to original source... Go to PubMed...
    10. Kleerekoper M, mendlovic DB. Sodium fluoride therapy of postmenopausal osteoporosis. Endocr Rev 1993; 14: 312-323. Go to original source... Go to PubMed...
    11. Masaryk P, Letkovská A, Stančíková M. Osteoporóza in Pavelka K, Rovenský J. Klinická revmatologie. Praha: Galén 2003: 614 s.
    12. Riggs BL, Hodgson SF, O´Fallon WM. Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis. N Engl J Med 1990; 322: 802-809. Go to original source... Go to PubMed...

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