Interní Med. 2007; 9(4): 175-177

Detection of premature atherosclerosis

MUDr. Jan Pi»ha CSc
Centrum výzkumu chorob srdce a cév, Laboratoř pro výzkum aterosklerózy, IKEM, Praha

The first manifestation of atherosclerosis could be a life threatening clinical event. Detection of preclinical atherosclerosis in asymptomatic patients is therefore of critical importance. Non-invasive screening of arteries for atherosclerosis is one of the best possibilities to reach this goal. Measurement of carotid intima-media thickness (CIMT) by highly sensitive ultrasound is one of the most promising methodologies. This methodology is able to improve risk assessment in an individual patient, further improve our knowledge about associations between risk factors for cardiovascular disease and atherosclerosis and in group of patients to monitor effect of antiatherosclerotic therapies. In spite of relative availability and simplicity of this measurement there are several serious methodological issues, which should be taken into account. In an individual patient CIMT could be used only for cardiovascular risk assessment. Progression of CIMT or effect of treatment is possible assess only in groups of 100–200 of patients.

Keywords: atherosclerosis, intima-media thickness, carotid arteries, ultrasound

Published: June 1, 2007  Show citation

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Pi»ha J. Detection of premature atherosclerosis. Interní Med. 2007;9(4):175-177.
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    References

    1. Bots MJ, M. de Jong TV, Hofman A, Grobee DE. Left, Right, Near or far wall commnon carotid intima-media thickness measurements: Associations with cardiovascular disease and lower extremity arterial atherosclerosis. J Clin Epidemiol 1997; 50, 7: 801-807. Go to original source... Go to PubMed...
    2. Burke GL, Evans GW, Riley WA, Sharett RA, Howard G, Barnes RW, Rosamond W, Crow R, Rautaharju PM, Heiss G. Arterial wall thickness is associated with prevalent cardiovascular disease in middle-aged adults. The Atherosclerosis Ris in Communities (ARIC) Study. Stroke. 1995; 26: 386-391. Go to original source... Go to PubMed...
    3. Crouse JR, Harpold GH, Kahl FR, Toole JF, McKinney WM. Evaluation of a scoring system of extracranial carotid atherosclerosis Extent With B-Mode Ultrasound. Stroke, Vol. 17, No 2, March-April 1986: 270-275. Go to original source... Go to PubMed...
    4. del Sol AI, Moons KG, Hollander M, Hofman A, Koudstaal PJ, Grobbee DE, Breteler MM, Witteman JC, Bots ML. Is carotid intima-media thickness useful in cardiovascular disease risk assessment? The Rotterdam Study. Stroke. 2001; 32: 1532-1538. Go to original source... Go to PubMed...
    5. Furberg CD, Adams HP Jr, Applegate WB, Byington RP, Espeland MA, Hartwell T, Hunninghake DB, Lefkowitz DS, Probstfield J, Riley WA, Young B, for the Asymptomatic Carotid Artery Progression (ACAPS) Research Group. Effect od lovastatin on early carotid atherosclerosis and cardiovascular events. Circulation 1994; 90: 1679-1687. Go to original source... Go to PubMed...
    6. Heiss G, Sharett AR, Barnes R, et al. Carotid atherosclerosis measured by B-Mode ultrasound in populations: Association with cardiovascular risk factors in the ARIC Study. Am J Epidemiol 1991; 134: 250-256. Go to original source... Go to PubMed...
    7. Hodis HN, Wendy JM, LaBree L, Selzer RH, Liu C, Azen SP. The role of carotid intima-media thickness in predicting clinical coronary events. Ann Intern. Med 1998; 128: 262-269. Go to original source... Go to PubMed...
    8. Chambless LE, Heiss G, Folsom AR, Rosamond W, Szklo M, Sharett AR, Clegg LX. Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987-1993. Am J Epidemiol. 1997; 146: 483-494. Go to original source... Go to PubMed...
    9. Kawamori R, Yamasaki Y, Matsushima H, et al. Detection of premature atherosclerosis in diabetic patients. Diabetes Care 1992; 15: 1290-1294. Go to original source... Go to PubMed...
    10. Mitchell JRA, Schwartz CJ. Relationship between arterial disease in different sites. Br Med J. 1962; 1: 1293-1301. Go to original source... Go to PubMed...
    11. Naghavi M, Falk E, Hecht HS, Jamieson MJ, Kaul S, Berman D, Fayad Z, Budoff MJ, Rumberger J, Naqvi TZ, Shaw LJ, Faergeman O, Cohn J, Bahr R, Koenig W, Demirovic J, Arking D, Herrera VL, Badimon J, Goldstein JA, Rudy Y, Airaksinen J, Schwartz RS, Riley WA, Mendes RA, Douglas P, Shah PK; SHAPE Task Force. From vulnerable plaque to vulnerable patient-Part III: Executive summary of the Screening for Heart Attack Prevention and Education (SHAPE) Task Force report. Am J Cardiol 2006; 98 (suppl2A): 2H-15H. Go to original source... Go to PubMed...
    12. O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. N Engl J Med 1999; 340: 14-22. Go to original source... Go to PubMed...
    13. Pignoli P, Tremoli E, Poli A, Oreste P, Paoleti R: Intimal plus media thickness of the arterial wall; a direct measurement with ultrasound imaging. Circulation 1986; 74: 1399-1406. Go to original source... Go to PubMed...
    14. Riley WA. Cardiovascular risk assessment in individual patients from carotid intimal-medial thickness measurements. Curr Atheroscler Rep. 2004; 6 (3): 225-231. Go to original source... Go to PubMed...
    15. Salonen JT, Salonen R. Ultrasonographically assessed carotid morphology and the risk of coronary heart disease. Arteriosclerosis 1991; 11: 1245-1249. Go to original source... Go to PubMed...
    16. Stuchlíková H, Pi»ha J, Szitányi P, Janda J. Moľnosti stanovení rizika rozvoje předčasné aterosklerózy zobrazovacími metodami v dětském věku. Čes.-slov. Pediat., 2005; 60, 5: 293-297.
    17. Wendelhag I, Gustavsson T, Suurkula M, Beeglund G, and Wikstrand J. Ultrasound measurement of wall thickness in the carotid artery: fundamental principles and description of a computerized analyzing system. Clinical Physiology 1991; 11: 565-577. Go to original source... Go to PubMed...

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