Interní Med. 2007; 9(7): 331-333

Nonmyeloablative allogeneic stem cell transplantation in the treatment of hematological malignancies

Luděk Raida

Hemato-onkologická klinika FN a LF UP v Olomouci

More than ten years allogeneic stem cell transplantations after non-myeloablative conditioning regimens have already been used in hematooncological practice. This concept of allografting is based on the estimation of severe recipient immunosuppression that allows to engraft the donor hematopoiesis including the key immunocompetent cells. A toxicity, risk of early serious non-hematological complications as well as transplant related mortality are significantly reduced with this approach. The shift from intensive conditionings to non-myeloablative ones means to relay on the posttransplant immunological mechanisms allowing an effective control and elimination of malignancy. Thus the risk of major immunological complications, a graft failure or rejection and graft versus host disease, is not reduced in allografting following the non-myeloablative conditioning. Nevertheless, the decrease of immediate toxicity and early posttransplant mortality allowed to widen the scale of allografting indications.

Keywords: allogeneic stem cell transplantation, non-myeloablative conditioning, reduced intensity conditioning, transplant related mortality, graft versus host disease, graft versus tumor reaction

Published: December 18, 2007  Show citation