Interní Med. 2008; 10(1): 26-30

Rationale antibiotic therapy with a focus on the newest antibiotic

doc. MUDr. Václav. Dostál

Oblastní nemocnice Jičín, LDN Nový Bydžov

Global situation forces experts to think about worsening situation in the efficacy of antimicrobial therapy. Antibiotic resistance increases in hospital and community pathogens both in systemic and local antibiotics. It is an interdisciplinary problem. An inappropriate antibiotic therapy causes a risk of antimicrobial resistance, drug toxicity and other complications of therapy. A preservation of antibiotic efficacy in future is determined by a rationale approach o anti-infective therapy and requires with a small number of exceptions a thorough patient examination. A team of specialists with a leading role of infectious diseases specialist should participate in the choice of antimicrobial therapy. The need for new antibiotic is necessary; their use however should be prudent. It is necessary to recommend their use only in selected situations. In most situations it is enough to use the current spectrum of medications, both in monotherapy or combinations. The paper reviews some of new antibiotics and their indications in infections caused by „problematic“ bacteria.

Keywords: new antibiotics, antibiotic resistance, empirical treatment, „problem“ bacteria, antibiotic policy

Published: April 1, 2008  Show citation