Interní Med. 2011; 13(9): 355-359

The MOTUDI study - influencing weight with insulin therapy in type 2 diabetes patients in the Czech Republic

prof.MUDr.Jindřiška Perušičová, DrSc.a studijní skupina

Interní klinika FN v Motole a 2. LF UK Praha

Insulin is still considered to be the most effective treatment in type 2 diabetes mellitus (T2DM) patients. However, concerns still remain about

gaining weight in association to insulin therapy. In our retrospective survey of 189 patients (105 women and 84 men) with T2DM who were

commenced on insulin therapy for poor diabetes control, we looked at the development of their weight and glycated haemoglobin in the first

years after switching to insulin. The mean age at diabetes diagnosis in our cohort was 50.7 years and the mean time from manifest diabetes

to initiation of insulin therapy was 9.7 years. The patients increased their weight from 85.53 kg at initiation of insulin therapy to 88.90 after

four years, but failed to reach the maximum weight they had had before detecting diabetes (91.78) and approached their weight at T2DM

diagnosis (87.98). The higher the patient‘s weight/BMI prior to diabetes, the greater was the weight loss prior to administering insulin, and

the longer the time period between manifest diabetes and initiation of insulin therapy, the higher was the decrease in BMI.

Keywords: insulin therapy, weight

Published: September 1, 2011  Show citation