Interní Med. 2012; 14(5): 224-226

The role of phytochemical substances in the prevention and treatment of tumors

doc.Ing.Zdeněk Zloch, CSc., MUDr.Pavel Sedláček
Ústav hygieny a preventivní medicíny, Lékařská fakulta UK, Plzeň

Since time immemorial, the folk medicine tries to cure diseases including tumors using various parts of plants. Numerous epidemiological

studies have shown that there is a statistically significant association between the frequency of consumption of foods of plant origin

and incidence of cancer. In an effort to determine the cause of their favourable effect, many natural substances have been isolated from

plants and their potential effects on different stages of carcinogenesis has been tested. Indeed, many from these substances hinder

or stop, in vitro, tumor development. The molecular mechanisms of these interactions have been elucidated. Nowadays, a lot of these

chemoprotective natural substances has been applied as means of primary and secondary prevention of tumors but not as remedies

for cancer.

Keywords: phytochemicals, cancer, chemopreventive substance

Published: May 14, 2012  Show citation

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Zloch Z, Sedláček P. The role of phytochemical substances in the prevention and treatment of tumors. Interní Med. 2012;14(5):224-226.
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References

  1. Abe S, Ishibashi H, Ikeda T, et al. AHCC in prevention of opportunistic infections. AHCC: Research and Commentary, 2009.
  2. Ulbricht CE, Wendy C. Phytochemicals in the oncology setting. Curr Treat Opt Oncol 2010; 11: 95-106. Go to original source... Go to PubMed...
  3. Kinghorn AD, Su BN, Jang DS, et al. Natural inhibitors of carcinogenesis. Planta Med 2004; 70: 691-705. Go to original source... Go to PubMed...
  4. Holst B, Williamson G. Nutrients and phytochemicals: from bioavailability to bioefficacy beyond antioxidants. Curr Opin Biotechnol 2008; 19: 73-82. Go to original source... Go to PubMed...
  5. Nathani R, Huma LC, Moriarty RM, et al. Comprehensive review of cancer chemopreventive agents evaluated in experimental carcinogenesis models and clinical trials. Curr Med Chem 2008; 15: 1044-1071. Go to original source... Go to PubMed...
  6. Amin AMRM, Kucuk O, Khuri FR, Shin DM. Perspectives for cancer prevention with natural compounds. J Clin Oncol 2009; 27(16): 2712-2723. Go to original source... Go to PubMed...
  7. Gibellini L, Pinti M, Naší M, et al. Quercetin and cancer chemoprevention. Evid-Bas compl Alter Med 2011, ID 591356: 1-15. Go to original source...
  8. Manson MM, Forman BE, Howells LM, Miseeva A. Determining the efficacy of dietary phytochemicals in cancer prevention. Biochem Soc Transact 2007; 35(5): 1358-1263. Go to original source... Go to PubMed...
  9. Matsui Y, Uhara J, Satoi S, et al. Improved prognosis of postoperative hepatocellular carcinoma patients when treated with functional foods: a prospective cohort study. J Hepatol 2002; 37(1): 78-86. Go to original source... Go to PubMed...
  10. Terakawa N, Matsui Y, Satoi S, et al. Immunological effect of active hexose correlated compound (AHCC) in healthy volunteers: a double-blind placebo-controlled trial. Nutr Canc 2008; 5: 643-651. Go to original source... Go to PubMed...
  11. Gullett NP, Amin ARMR, Bayraktar S, et al. Cancer prevention with natural compounds. Sem Oncol 2010; 37: 258-281. Go to original source... Go to PubMed...
  12. Dai J, Mumlej RJ. Plant phenolics: extraction, analysis and thein antioxidant and anticancer properties. Molec 2010; 15: 7313-7352. Go to original source... Go to PubMed...
  13. Zhang HY, Chen LL, Li XJ, Zhang J. Evolutionary inspirations for drug discovery. TRENDS Pharmacol Sci 2010; 31: 443-448. Go to original source... Go to PubMed...




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