Interní Med. 2012; 14(12): 461-464

New insights in pathogenesis and treatment of iron deficiency nad iron overload

doc.MUDr.Jaroslav Čermák, CSc.

Ústav hematologie a krevní transfuze, Praha

New mechanisms involved in pathogenesis of iron deficiency nad iron overload has been reported within past twenty years. A regulation

of intracellular iron level caused by control of synthesis of proteins involved in iron metabolism by labile free cytoplasmic iron via

binding of IRP on mRNA IRE has been described. Hepcidin represents an essential regulator of iron output from cells to circulation.

Substitution of iron still represents the main treatment approach to patients with iron deficiency. A concomitant administration od iron

in patients with anemia of chronic disease treated with erythropoetin has been recently discussed. New oral iron chelators represent

a significant improvement in the treatment of iron overload and their administration enabled a switch from the treatment to effective

prophylaxis of iron overload.

Keywords: iron overload, iron deficiency, pathogenesis, treatment

Published: January 1, 2013  Show citation