Interní Med. 2013; 15(6-7): 195-200

Renal sympathetic denervation and pharmacotherapy with the respect of renal function

prof.MUDr.Vladimír Teplan, DrSc.

Klinika nefrologie TC IKEM, Subkatedra nefrologie IPVZ, Praha

in management of serious hypertension

Sympathetic nervous system plays significant role in pathophysiology of hypertension. New method in its management is cathether- based

radiofrequency ablation of the sympathetic nerves located around renal arteries. Comparing to dilatation of renal artery stenosis renal,

renal denervation (RDN) shows promising long lasting decrease of blood pressure. RDN is indicated in resistent hypertension (three different

antihypertensive drugs icl. diuretic are not effective in correction of serious hypertension) with a risk of organ damage following heart

and kidney failure. It is supposed, RDN could be effectively used also in patients with decreased renal function and refractory hypertension.

In our pilots studies we confirmed no signifficant adverse effect on renal function in 12 months follow-up. On the other hand, it should be

focus on sufficient correction of blood pressure in indivualized combination of antihypertensive drugs mainly central symphaticolytics.

Keywords: resistent hypertension, renal sympathetic denervation, radiofrequency ablation, pharmacotherapy, renal function

Published: July 15, 2013  Show citation