Interní Med. 2014; 16(6): 228-230

Single pill combination therapy - the future of antihypertensive treatment?

doc.MUDr.Jan Václavík, Ph.D.
I. interní klinika &ndash, kardiologická, LF UP a FN Olomouc

This article reviews the current principles of antihypertensive combination therapy and recommended drug combinations. Causes of

inadequate hypertension control both on patient and physician side are discussed. A growing palette of fixed combinations of two

antihypertensive drugs and now also a fixed combination of three drugs in one pill opens new horizons in the antihypertensive therapy.

A new concept of antihypertensive treatment is presented – treatment of hypertension by a single pill. This concept seems to be suitable

and applicable to the majority of hypertensive patients encountered in daily practice.

Keywords: hypertension, treatment, fixed combination, new concept – single pill treatment

Published: December 16, 2014  Show citation

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Václavík J. Single pill combination therapy - the future of antihypertensive treatment? Interní Med. 2014;16(6):228-230.
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    References

    1. Mancia G, Fagard R, Narkiewicz K, Redón J, Zanchetti A, Böhm M, Christiaens T, Cifkova R, De Backer G, Dominiczak A, Galderisi M, Grobbee DE, Jaarsma T, Kirchhof P, Kjeldsen SE, Laurent S, Manolis AJ, Nilsson PM, Ruilope LM, Schmieder RE, Sirnes PA, Sleight P, Viigimaa M, Waeber B, Zannad F. Task Force Members. 2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2013; 31(7): 1281-357. Go to original source... Go to PubMed...
    2. Dickerson JE, Hingorani AD, Ashby MJ, Palmer CR, Brown MJ. Optimisation of antihypertensive treatment by crossover rotation of four major classes. Lancet. 1999; 353(9169): 2008-2013. Go to original source... Go to PubMed...
    3. Deary AJ, Schumann AL, Murfet H, Haydock SF, Foo RS, Brown MJ. Double-blind, placebo-controlled crossover comparison of five classes of antihypertensive drugs. J Hypertens. 2002; 20(4): 771-777. Go to original source... Go to PubMed...
    4. Epstein M, Bakris G. Newer approaches to antihypertensive therapy. Use of fixed-dose combination therapy. Arch Intern Med. 1996; 156(17): 1969-1978. Go to original source...
    5. Wald DS, Law M, Morris JK, Bestwick JP, Wald NJ. Combination therapy versus monotherapy in reducing blood pressure: meta-analysis on 11,000 participants from 42 trials. Am J Med. 2009; 122(3): 290-300. Go to original source... Go to PubMed...
    6. Filipovský J, Widimský J Jr, Ceral J, Cífková R, Horký K, Linhart A, Monhart V, Rosolová H, Seidlerová J, Souček M, Špinar J, Vítovec J, Widimský J; Czech Hypertension Society. Diagnosis and treatment of arterial hypertension. 2012 Guidelines of the Czech Hypertension Society]. Vnitr Lek. 2012; 58(10): 785-801. Go to PubMed...
    7. Bakris GL. The importance of blood pressure control in the patient with diabetes. Am J Med. 2004; 116(Suppl 5A): 30S-38S. Go to original source... Go to PubMed...
    8. Falaschetti E, Mindell J, Knott C, Poulter N. Hypertension management in England: a serialcross-sectional study from 1994 to 2011. Lancet. 2014; 383(9932): 1912-1919. Go to original source... Go to PubMed...
    9. McManus RJ, Mant J. The drugs do work: blood pressure improvement in England. Lancet. 2014; 383(9932): 1868-1869. Go to original source... Go to PubMed...
    10. Egan BM, Zhao Y, Axon RN, Brzezinski WA, Ferdinand KC. Uncontrolled and apparent treatment resistant hypertension in the United States, 1988 to 2008. Circulation. 2011; 124(9): 1046-1058. Go to original source... Go to PubMed...
    11. Bramlage P, Böhm M, Volpe M, Khan BV, Paar WD, Tebbe U, Thoenes M. A global perspective on blood pressure treatment and control in a referred cohort of hypertensive patients. J Clin Hypertens (Greenwich). 2010; 12(9): 666-677. Go to original source... Go to PubMed...
    12. Cífková R, Skodová Z, Bruthans J, Adámková V, Jozífová M, Galovcová M, Wohlfahrt P, Krajcoviechová A, Poledne R, Stávek P, Lánská V. Longitudinal trends in major cardiovascular risk factors in the Czech population between 1985 and 2007/8. Czech MONICA and Czech post-MONICA. Atherosclerosis. 2010; 211(2): 676-681. Go to original source... Go to PubMed...
    13. Jin J, Sklar GE, Min Sen Oh V, Chuen Li S. Factors affecting therapeutic compliance: A review from the patient's perspective. Ther Clin Risk Manag. 2008; 4(1): 269-286. Go to original source... Go to PubMed...
    14. Mazzaglia G, Mantovani LG, Sturkenboom MC, Filippi A, Trifir? G, Cricelli C, Brignoli O, Caputi AP. Patterns of persistence with antihypertensive medications in newly diagnosed hypertensive patients in Italy: a retrospective cohort study in primary care. J Hypertens. 2005; 23(11): 2093-2100. Go to original source... Go to PubMed...
    15. Bangalore S, Kamalakkannan G, Parkar S, Messerli FH. Fixed-dose combinations improve medication compliance: a meta-analysis. Am J Med. 2007; 120(8): 713-719. Go to original source... Go to PubMed...
    16. Egan BM, Bandyopadhyay D, Shaftman SR, Wagner CS, Zhao Y, Yu-Isenberg KS. Initial monotherapy and combination therapy and hypertension control the first year. Hypertension. 2012; 59(6): 1124-1131. Go to original source... Go to PubMed...
    17. Gerbino PP, Shoheiber O. Adherence patterns among patients treated with fixed-dose combination versus separate antihypertensive agents. Am J Health Syst Pharm. 2007; 64(12): 1279-1283. Go to original source... Go to PubMed...
    18. Tóth K. PIANIST Investigators. Antihypertensive efficacy of triple combination perindopril/indapamide plus amlodipine in high-risk hypertensives: results of the PIANIST study (Perindopril-Indapamide plus AmlodipiNe in high rISk hyperTensive patients). Am J Cardiovasc Drugs. 2014; 14(2): 137-145. doi: 10.1007/s40256-014-0067-2. Erratum in: Am J Cardiovasc Drugs. 2014; 14(3): 239. Go to original source... Go to PubMed...

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