Interní Med. 2014; 16(6): 247-250

Role of multidisciplinary team in the treatment of the advanced colorectal cancer

prof.MUDr.Miroslav Ryska, CSc.1,2
1 Chirurgická klinika 2. LF UK a ÚVN, Praha
2 Fakulta zdravotnictva a sociální práce, Trnavská univerzita, Trnava

Effective diagnostic – therapeutic approach to patients with metastatic colorectal carcinoma leads to more than 50 % 5 year survival. Most

effective treatment is curable liver resection with primary indication in 20 % of patients. Other 15–20 % patients reach resection after

conversion systemic antitumor therapy. There are special techniques (combined procedures, two stages operations) or portal venous

embolisation followed by resection after hypertrophy of liver remnant. Multidisciplinary approach is only the condition for successful

treatment on the base of personalized medicine principles in these patients.

Keywords: advanced colorectal carcinoma, resection, multidisciplinary team

Published: December 16, 2014  Show citation

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Ryska M. Role of multidisciplinary team in the treatment of the advanced colorectal cancer. Interní Med. 2014;16(6):247-250.
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    32. Adson MA, Van Heerden JA: Major hepatic resection for metastatic colorectal cancer. Ann Surg 1980; 191: 576-583¨. Go to original source... Go to PubMed...
    33. Abdalla EK, Vauthey JN, Ellis LM, et al: Recurrence and outcomes following hepatic resection, radiofrequency ablation and combined resectio/ablation for colorectal liver metastases. Ann Surg 2004; 239: 818-825. Go to original source... Go to PubMed...
    34. Adam R, De Gramont A, Figueras J, et the EGOSLIM (Expert group on oncosurgery management of liver metastases) group: The oncosurgery approach to managing liver metastases from colorectal cancer: A multidisciplinary international consensus. The Oncologist 2012; 17: 1225-1239. Go to original source... Go to PubMed...
    35. Shackelford RE, Whitling NA, McNab P, et al. KRAS testing: a tool for the implementation of personalized medicine. Genes & Cancer 2012; 3: 459-466. Go to original source... Go to PubMed...
    36. Kaczirek K, Tamandl D, Klinger M, et al. Criteria for resectability of colorectal cancer liver metastases - an Austria survey and current recommendations. Eur Surg 2009; 41: 213-220. Go to original source...
    37. Tan-Tam C, Chung SW. Minireview on laparoscopic hepatobiliary and pancreatic surgery. World J Gastrointest Endosc 2014; 6: 60-67. Go to original source... Go to PubMed...
    38. de Jong MC, van Dam RM, Maas M, et al. The liver-first approach for synchronous colorectal liver metastasis: a 5-year single-centre experience. HPB 2011; 13: 745-752. Go to original source... Go to PubMed...
    39. Nordlinger B, Sorbye H, Glimelius B, et al. Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial. Lancet 2008; 371: 1007-1016. Go to original source... Go to PubMed...
    40. Mitry E, Fields ALA, Bleiberg H, et al. Adjuvant chemotherapy after potentially curative resection of metastases from colorectal cancer: A pooled analysis of two randomized trials. J Clin Oncol 2008; 26: 4906-4911. Go to original source... Go to PubMed...
    41. Pawlik TM, Scoggins CR, Zorzi D, et al: Effect of surgical margin status on survival and site of recurrence after hepatic resection for colorectal metasttases. Ann Surg 2005; 241: 715-722. Go to original source... Go to PubMed...
    42. Jonas S, Thelen A, Benckert C, et al. Extended resections of liver metastases from colorectal cancer. World J Surg 2007; 31: 511-521. Go to original source... Go to PubMed...
    43. Thelen A, Jonas S, Benckert C, et al. Repeat liver resetion for recurrent liver metastases from colorectal cancer. Eur J Surg Oncol 2007; 33: 324-328. Go to original source... Go to PubMed...
    44. Venderbosch S, de Wilt JH, Teerenstra S, et al. Prognostic value of resection of primary tumor in patients with stage IV colorectal cancer: Retrospective analysis of two randomized studies and a review of the literature. Ann Surg Oncol 2011; 18: 3252-3260. Go to original source... Go to PubMed...
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    51. Vauthey JN, Pawlik TM, Ribero D, et al. Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic coolorectal metastases. J Clin Oncol 2006; 24: 2065-2072. Go to original source... Go to PubMed...
    52. Azoulay D, Casting D, Smail A, et al. Resection of nonresectable liver metastases from colorectal cancer after percutaneous portal vein embolisation. Ann Surg 2000; 231: 480-486. Go to original source... Go to PubMed...
    53. Adam R, Laurent A, Azoulay D, et al. Two-stage hepatectomy: a planned strategy to treat irresectable liver tumors. Ann Surg 2000; 232: 777-785. Go to original source... Go to PubMed...
    54. Lencioni R, Crocetti L, Cioni D, et al: Percutaneous RFA of hepatic colorectal metastases: technice, indications, results, and new promises. Invest Radiol 2004; 39: 689-697. Go to original source... Go to PubMed...
    55. Ryska M, Pantoflíček J, Dušek L. Léčba jaterních metastáz kolorektálního původu v České republice: současný celostátní survey. Rozhl Chir 2010; 89: 100-108. Go to PubMed...
    56. Kopetz S, Chang GJ, Overman MJ, et al. Improved survival in metastatic colorectal cancer Is associated with adoption of hepatic resection and improved chemotherapy. J Clin Oncol 2009; 27: 3677-3683. Go to original source... Go to PubMed...
    57. Ismaili N. Treatment of colorectal liver metastases. WJSO 2011; 9: 154. Go to original source... Go to PubMed...
    58. Vyzula R, et al. Modrá kniha České onkologické společnosti, 2014; 18: 69.

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