Interní Med. 2017; 19(5): 274-278 | DOI: 10.36290/int.2017.060

Differential diagnosis of monoclonal gammopathies from the point of clinical practice
I. Malignant monoclonal gammopathies

prof. MUDr. Vlastimil Ščudla, CSc.^1,2, doc. MUDr. Mgr. Jiří Minařík, Ph.D.², MUDr. Tomáš Pika, Ph.D.², doc. MUDr. Jaroslav Bačovský, CSc.²

¹ III. interní klinika – nefrologická, revmatologická a endokrinologická, Fakultní nemocnice Olomouc

² Hemato-onkologická klinika FN a LF UP v Olomouci

Monoclonal gammopathies (MG) are a very heterogeneous group of malignant and non-malignant conditions, that are characterizedby the presence of monoclonal immunoglobulin (MIg, „paraprotein“) or its structural components in serum and/or urine. Thepresented paper shows contemporary classification of MG, list of standard as well as specialized examination methods, and an effectivedifferential diagnosis for an early recognition of malignant MG requiring therapy. The manuscript contains also the overviewof contemporary algorithms for assessment, and sets of diagnostic criteria of the most frequent malignant MG for routine practice.

Keywords: monoclonal gammopathy, multiple myeloma, Waldenström macroglobulinemia, solitary plasmacytoma, plasma cell
leukemia, POEMS syndrome, differential diagnosis

Received: October 30, 2017; Accepted: November 8, 2017; Published: December 1, 2017  Show citation