Interní Med. 2018; 20(1): 44-48 | DOI: 10.36290/int.2018.051

Differential diagnosis of monoclonal gammopathies from the point of clinical practice
II. Monoclonal gammopathy of undetermined significance and other monoclonal gammopathies of the „non-malignant“ origin

prof. MUDr. Vlastimil Ščudla, CSc.^1,2, doc. MUDr. Mgr. Jiří Minařík, Ph.D.², MUDr. Tomáš Pika, Ph.D.², doc. MUDr. Jaroslav Bačovský, CSc.²

¹ 3. interní klinika NRE LF UP a FN v Olomouci

² Hemato-onkologická klinika FN a LF UP v Olomouci

Monoclonal gammopathies (MG) are a very heterogeneous group of both malignant and dominantly non-malignant conditionsthat are characterized by the presence of monoclonal immunoglobulin (MIg, „paraprotein“) or its structural components in serumand/or urine. The aim of this paper is to present the spectrum of „non-malignant“ MG, their diagnostics and differential diagnosticsfrom the point of primary health care. The paper includes diagnostic criteria of selected nosologocal units, especially monoclonalgammopathy of undetermined significance (MGUS) and its subtypes, monoclonal gammopathy of renal significance (MGRS),AL-amyloidosis and light chain deposition disease (LCDD), including their position in routine clinical practice.

Keywords: monoclonal gammopathy, monoclonal gammopathy of undetermined significance, monoclonal gammopathy of
renal significance, AL amyloidosis, light chain deposition disease, differential diagnosis

Received: April 20, 2017; Accepted: April 20, 2017; Published: March 1, 2018  Show citation