Interní Med. 2007; 9(4): 163-166

The treatment of lipid disorders in diabetic patients

doc. MUDr. Vladimír Soška CSc^1,2

¹ Oddělení klinické a radiační onkologie, FN u svaté Anny v Brně

² Centrum pro diagnostiku a léčbu dyslipidemií, FN u sv. Anny v Brně

The prevalence of lipid disorders in diabetic patients is very high. It is necessary to differentiate between secondary dyslipidemia caused by insufficient diabetes compensation and dyslipidemia as a separate disorder associated with diabetes mellitus. The combined hyperlipidemia is a typical finding, frequently associated with a decrease of HDL-cholesterol. Frequently we encounter also an increase of apolipoprotein B100 and increased concentration of small LDL3. Target blood levels of lipids are the same as in patients in secondary prevention of cardiovascular diseases. A good control of diabetes, optimizing of body weight, dietary changes and regular physical activity are essential in the treatment. If these measures do not lead to improvement in lipid profile, therapy with hypolipidemics is indicated. The choice of medications should reflect the type of dyslipidemia. Reaching of target levels of LDL-cholesterol or non HDL-cholesterol are the principal goal of treatment. A combined therapy with a statin and a fibrate is indicated in a large number of patients.

Keywords: dyslipidemia, diabetes mellitus, non HDL-cholesterol, apolipoprotein B, triacylglycerols, LDL-cholesterol

Published: June 1, 2007  Show citation